Alpha Fetoprotein |
Lume Disease SerologyLyme disease is a multisystem disorder characterized by dermatologic, neurologic, cardiac, and rheumatic manifestations in various stages. Epidemiologic and serologic studies implicate a common tickborne spirochete, Borrelia burgdoiferi, as the causative agent. Serologic tests are able to identify 50% of patients with early-stage Lyme disease and all patients with later complications of carditis, neuritis, and arthritis or who are in remission. The test uses one of three methods: Western blot test, enzyme-linked immunosorbent assay (ELISA), or indirect immunofluorescent assay. ELISA is used as a screening test for identification of infection or past exposure. The Western blot test for immunoglobulin (lgG) antibody and the indirect immunofluorescent assay for IgM antibodies to B. burgdorferi are automatically performed to confirm reactive ELISA results greater than 1.0 index. Purpose
Patient preparation
Procedure and posttest care
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Reference values Normal serum values are nonreactive for the ELISA method; the index is less than 1.0. Normal results for the Western blot test are negative for IgM; IgG of less than or equal to 4 bands is nonconfirmatory. Normal titer for the indirect immunofluorescent assay is less than 1:256. Abnormal findingsA positive Lyme serology can help confirm diagnosis but isn't definitive. Other treponemal diseases and high rheumatoid factor titers can cause false-positive results. More than 15% of patients with Lyme disease fail to develop antibodies. Interfering factors
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