Alpha Fetoprotein |
Torch TestThis test helps detect exposure to pathogens involved in congenital and neonatal infections. TORCH is an acronym for toxoplasmosis, rubella, cytomegalovirus, and herpes simplex antibodies. These pathogens are commonly associated with congenital and neonatal infections that aren't clinically apparent and may cause severe central nervous system impairment. This test detects specific immunoglobulin M-associated antibodies in infant blood. Purpose
Patient preparation
Procedure and posttest care
Precautions
Normal FindingsNormal test result is negative for TORCH agents. Abnormal findingsToxoplasmosis is diagnosed by sequential examination that shows rising antibody titers, changing titers, and serologic conversion from negative to positive; a titer of 1:256 suggests recent Toxoplasma infection. In infants less than 6 months old, rubella infection is associated with a marked and persistent rise in complement-fixing antibody titer over time. Persistence of rubella antibody in an infant after age 6 months strongly suggests congenital infection. Congenital rubella is associated with cardiac anomalies, neurosensory deafness, growth retardation, and encephalitic symptoms. Detection of herpes antibodies in cerebrospinal fluid with signs of herpetie encephalitis and persistent herpes simplex virus type 2 antibody levels confirms herpes simplex infection in a neonate without obvious herpetic lesions. Interfering factors
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